CAS No. 64-77-7

Batch: Purity:99.88
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Tolbutamide (HLS 831) Chemical Structure
Chemical Structure
Check the Tolbutamide (HLS 831) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 1-butyl-3-(4-methylphenyl)sulfonylurea
CAS Number 64-77-7
Molecular Formula

C12H18N2O3S
Molecular Weight (MW) 270.35
SMILES CCCCNC(=O)NS(=O)(=O)C1=CC=C(C=C1)C
InChIKey JLRGJRBPOGGCBT-UHFFFAOYSA-N

Biological Activity

Tolbutamide is a sulfonylurea inhibitor of ATP-sensitive potassium (KATP) channels. By blocking KATP channels in pancreatic beta cells, it induces cell membrane depolarization, opening voltage-gated calcium channels to stimulate insulin release. Downstream, increased insulin secretion enhances cellular glucose uptake and lipid synthesis in adipose tissue, supporting its application in type 2 diabetes and metabolic research. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 54 mg/mL (199.74 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 54 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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Reference

[1] Gribble FM, et al. EMBO J. 1997;16(6):1145-52.

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Note: Technical data last updated: Sep 1, 2026.