CAS No. 477600-75-2

Batch: Purity:99.95
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Tofacitinib (CP-690550) Chemical Structure
Chemical Structure
Check the Tofacitinib (CP-690550) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 3-[(3R,4R)-4-methyl-3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl]-3-oxopropanenitrile
CAS Number 477600-75-2
Molecular Formula

C16H20N6O
Molecular Weight (MW) 312.37
SMILES CC1CCN(CC1N(C)C2=NC=NC3=C2C=CN3)C(=O)CC#N
InChIKey UJLAWZDWDVHWOW-YPMHNXCESA-N

Ordering Information

Biological Activity

Tofacitinib (CP-690550) is a potent Janus kinase inhibitor targeting JAK3, as well as JAK1 and JAK2. It suppresses cytokine-induced immune signaling and reduces downstream inflammatory responses. Tofacitinib effectively inhibits immune reactions in allogeneic tissue transplantation, significantly prolonging graft survival in murine heterotopic heart transplant models and preventing allograft rejection in non-human primates. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 62 mg/mL (198.48 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.