CP-690550 (Tofacitinib) Citrate Clinical Trials

Size	Price	Qty
10mg	USD 147
50mg	USD 470

Clinical Trials

Numerous clinical trials spanning Phase 1 through Phase 4 evaluate Tofacitinib citrate across various recruitment statuses, including completed, actively recruiting, enrolling by invitation, and withdrawn protocols. These studies target diverse inflammatory, autoimmune, and dermatological conditions, such as rheumatoid arthritis, ulcerative colitis, alopecia areata, immune-mediated colitis, and ANCA-associated vasculitis. Research initiatives are sponsored by both major pharmaceutical companies, such as Pfizer and Gilead Sciences, and leading academic institutions, including Columbia University.

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT07281456	RECRUITING	Sjogren's Syndrome	National Institute of Dental and Craniofacial Research (NIDCR)	2025-12-18	PHASE2
NCT07598643	RECRUITING	Down Syndrome	University of Colorado, Denver	2026-05-28	PHASE2
NCT07352566	NOT_YET_RECRUITING	Psoriasis; Atopic Dermatitis	University of California, San Francisco	2026-08-01	PHASE4
NCT06301373	RECRUITING	Rheumatoid Arthritis	Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University	2024-09-01
NCT07522801	NOT_YET_RECRUITING	LAL	Philippe ROUSSELOT	2026-09-01	PHASE2
NCT06654882	RECRUITING	Polyarticular Course Juvenile Idiopathic Arthritis (JIA)	Duke University	2026-01-09	PHASE3
NCT06687551	RECRUITING	Rheumatoid Arthritis (RA	University Hospital, Toulouse	2025-06-06	PHASE4
NCT04871191	RECRUITING	Granulomatosis With Polyangiitis; Anti-neutrophil Cytoplasmic Antibody-associated Vasculitis	Assistance Publique - Hôpitaux de Paris	2025-06-06	PHASE3
NCT07530367	NOT_YET_RECRUITING	Palmoplantar Pustulosis (PPP)	Second Affiliated Hospital, Zhejiang University, School of Medicine	2026-08-01	PHASE3
NCT03414502	RECRUITING	Rheumatoid Arthritis	University of Nebraska	2007-12-10	PHASE3
NCT07138898	RECRUITING	Rheumatic Disease	NYU Langone Health	2025-12-12	PHASE2
NCT07547930	RECRUITING	Thyroid Eye Disease, TED; Graves Ophthalmopathy; Graves Orbitopathy	The First Affiliated Hospital of Xiamen University	2026-04-24	PHASE2
NCT06660329	ENROLLING_BY_INVITATION	Blau Syndrome	Peking Union Medical College Hospital	2024-10-01	PHASE4
NCT07406035	RECRUITING	Psoriatic Arthritis	Chia Tai Tianqing Pharmaceutical Group Nanjing Shunxin Pharmaceutical Co., Ltd.	2026-07-16	PHASE2
NCT06095128	RECRUITING	Ulcerative Colitis	Takeda	2024-06-12	PHASE4
NCT07343635	RECRUITING	Erythematotelangiectatic Rosacea	The Fourth Affiliated Hospital of Zhejiang University School of Medicine	2026-02-01
NCT06698822	RECRUITING	Cutaneous T-Cell Lymphoma	M.D. Anderson Cancer Center	2025-03-10	PHASE2
NCT07297069	NOT_YET_RECRUITING	Acute Severe Ulcerative Colitis	Asian Institute of Gastroenterology, India	2026-01-01	PHASE2
NCT04624230	ACTIVE_NOT_RECRUITING	Ulcerative Colitis	Pfizer	2021-08-12	PHASE3
NCT07636057	NOT_YET_RECRUITING	Rheumatoid Arthritis (RA)	Sheikh Zayed Federal Postgraduate Medical Institute	2026-07-05	PHASE4
NCT06945666	NOT_YET_RECRUITING	Rheumatoid Arthritis (RA	Jie Chang	2025-08-01	PHASE4
NCT07131813	RECRUITING	Oral Lichen Planus	All India Institute of Medical Sciences, Bhubaneswar	2025-10-10	PHASE4
NCT07313072	NOT_YET_RECRUITING	Nail Psoriasis	Hexsel Dermatology Clinic	2026-03	PHASE2
NCT07055529	NOT_YET_RECRUITING	Vitiligo, Generalized	Hayat Abad Medical Complex, Peshawar	2026-06-01	EARLY_PHASE1
NCT07581418	NOT_YET_RECRUITING	Chronic Plaque Psoriasis	Pak Emirates Military Hospital	2026-06-01
NCT06707246	RECRUITING	Hidradenitis Suppurativa	Second Affiliated Hospital, Zhejiang University, School of Medicine	2024-12-15
NCT07008846	ACTIVE_NOT_RECRUITING	Moderate to Severe Rheumatoid Arthritis	Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh	2025-05-10	PHASE3
NCT07554820	RECRUITING	Rheumatoid Arthritis; Major Adverse Cardiac Events	Shaikh Zayed Hospital, Lahore	2025-12-06	PHASE4
NCT07406204	NOT_YET_RECRUITING	Alopecia Areata; Alopecia Totalis (AT); Alopecia Universalis	Hayat Abad Medical Complex, Peshawar	2026-02-15	PHASE4
NCT06119490	RECRUITING	Toxic Epidermal Necrolysis	Peng Zhang	2023-07-05	EARLY_PHASE1
NCT06498089	RECRUITING	Takayasu Arteritis	Shanghai Zhongshan Hospital	2024-06-28	PHASE4
NCT05845723	RECRUITING	Aneurysm; Behcet Syndrome, Vascular Type	Peking Union Medical College Hospital	2023-06-01	PHASE2
NCT05662228	COMPLETED	Down Syndrome; Regression	University of Colorado, Denver	2023-06-29	PHASE2
NCT05104723	COMPLETED	Chronic Granulomatous Disease; Inflammatory Gastrointestinal Disease; Inflammatory Skin Disease; Inflammatory Lung Disease	National Institute of Allergy and Infectious Diseases (NIAID)	2022-08-12	PHASE1; PHASE2
NCT06176508	UNKNOWN	Psoriatic Arthritis	Hansoh BioMedical R&D Company	2024-02-26	PHASE2
NCT05151848	UNKNOWN	Takayasu Arteritis	Chinese SLE Treatment And Research Group	2022-01-05	PHASE4
NCT06020144	ACTIVE_NOT_RECRUITING	Rheumatoid Arthritis	Hangzhou Highlightll Pharmaceutical Co., Ltd	2023-11-15	PHASE3
NCT05102448	RECRUITING	Takayasu Arteritis	Shanghai Zhongshan Hospital	2021-11-01	PHASE4
NCT07261306	RECRUITING	Psoriasis	Lahore General Hospital	2025-08-29	EARLY_PHASE1
NCT05112263	UNKNOWN	Ulcerative Colitis	Post Graduate Institute of Medical Education and Research, Chandigarh	2023-07-01
NCT06689982	NOT_YET_RECRUITING	Amyotrophic Lateral Sclerosis	Beijing Tiantan Hospital	2024-12-01	EARLY_PHASE1
NCT04743518	RECRUITING	Ulcerative Colitis	Centre Hospitalier Universitaire, Amiens	2021-02-02	PHASE4
NCT05313620	RECRUITING	Ulcerative Colitis; Thromboembolism	Fundación de Investigación Biomédica - Hospital Universitario de La Princesa	2022-04-01	PHASE4
NCT06625450	NOT_YET_RECRUITING	Ulcerative Colitis	Post Graduate Institute of Medical Education and Research, Chandigarh	2024-10	PHASE4
NCT03681275	RECRUITING	Diaphragm Injury	Stanford University	2019-09-03	PHASE2
NCT06393972	NOT_YET_RECRUITING	Glucocorticoid Resistant ICIs-related Myocarditis	Shanghai Zhongshan Hospital	2024-07-01	PHASE2
NCT06465732	UNKNOWN	Atopic Dermatitis	Second Affiliated Hospital, Zhejiang University, School of Medicine	2025-01	PHASE4
NCT06998875	RECRUITING	Primary Cutaneous Amyloidosis	Army Medical University, China	2025-03-01	PHASE4
NCT07044141	ACTIVE_NOT_RECRUITING	Vitiligo	Lahore General Hospital	2025-03-01	PHASE1
NCT06172361	RECRUITING	Polymyalgia Rheumatica	Zhejiang University	2024-01-20	PHASE3
NCT06810050	COMPLETED	Atopic Dermatitis (AD)	CAGE Bio Inc.	2024-12-18	PHASE2
NCT07472166	COMPLETED	Scleroderma, Systemic	Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh	2024-12-21	PHASE4
NCT06923228	COMPLETED	Atopic Dermatitis (AD)	CAGE Bio Inc.	2025-04-21	PHASE2
NCT05749666	UNKNOWN	Takayasu Arteritis	Chinese SLE Treatment And Research Group	2023-01-20	PHASE3
NCT06201715	UNKNOWN	Prurigo Nodularis; Itch	Second Affiliated Hospital, Zhejiang University, School of Medicine	2024-05-01
NCT06474078	COMPLETED	Stevens-Johnson Syndrome; Toxic Epidermal Necrolysis	Chang Gung Memorial Hospital	2022-08-01
NCT05348213	RECRUITING	Diffuse Large B Cell Lymphoma	Ruijin Hospital	2022-05-16	PHASE2
NCT06112665	RECRUITING	Axial Spondyloarthritis	Charite University, Berlin, Germany	2023-11-10	PHASE4
NCT03976245	RECRUITING	Rheumatoid Arthritis	London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's	2020-03-01	PHASE4
NCT05326464	COMPLETED	Glioblastoma	University of Texas Southwestern Medical Center	2022-10-07	PHASE3
NCT01500551	COMPLETED	Juvenile Idiopathic Arthritis	Pfizer	2013-03-18	PHASE2; PHASE3
NCT05803135	UNKNOWN	Rheumatoid Arthritis	Nanfang Hospital, Southern Medical University	2023-03-31	PHASE4
NCT04496960	ACTIVE_NOT_RECRUITING	Sjogren's Syndrome	National Institute of Dental and Craniofacial Research (NIDCR)	2021-05-18	PHASE1; PHASE2
NCT03885713	COMPLETED	Inflammatory Bowel Diseases; Crohn Disease; Ulcerative Colitis	Fundación de Investigación Biomédica - Hospital Universitario de La Princesa	2019-09-10	PHASE4
NCT04246372	COMPLETED	Down Syndrome; Alopecia Areata; Atopic Dermatitis / Eczema; Hidradenitis Suppurativa; Vitiligo; Psoriasis	University of Colorado, Denver	2020-10-21	PHASE2
NCT04610476	UNKNOWN	Psoriatic Arthritis; Withdrawal; Reduction	University of Erlangen-Nürnberg Medical School	2020-10-19	PHASE3
NCT06011343	UNKNOWN	Cutaneous Leishmaniasis, American	Hospital Universitário Professor Edgard Santos	2023-10-01	PHASE2; PHASE3
NCT06438679	ENROLLING_BY_INVITATION	Dermatomyositis	Second Affiliated Hospital, Zhejiang University, School of Medicine	2024-03-19	PHASE4
NCT06202560	COMPLETED	Frontal Fibrosing Alopecia; Lichen Planopilaris of Scalp	Institute of Dermatology, Thailand	2023-11-29
NCT03591770	TERMINATED	Inflammatory Bowel Diseases	Boston Medical Center	2019-07-31	PHASE4
NCT04944524	UNKNOWN	Granulomatosis With Polyangiitis	Shanghai Zhongshan Hospital	2021-07-01	PHASE4
NCT05606107	UNKNOWN	Rheumatoid Arthritis	Second Affiliated Hospital, Zhejiang University, School of Medicine	2022-05-20	PHASE4
NCT06114407	UNKNOWN	Spondyloarthritis, Axial	Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh	2023-10-30	PHASE2
NCT05814939	COMPLETED	Active Ankylosing Spondylitis	Jiangsu vcare pharmaceutical technology co., LTD	2023-04-26	PHASE2
NCT06044844	UNKNOWN	Efficacy of Tofacitinib in the Systemic Sclerosis	Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh	2023-11	PHASE2
NCT05080218	COMPLETED	Rheumatoid Arthritis; Psoriatic Arthritis; Spondylarthritis	Jeffrey Curtis	2021-11-15	PHASE4
NCT04485325	COMPLETED	Rheumatic Arthritis	Dr. Frank Behrens	2019-11-04	PHASE4
NCT03000439	COMPLETED	Arthritis Juvenile Idiopathic	Pfizer	2018-05-10	PHASE3
NCT04431895	COMPLETED	Myasthenia Gravis, Generalized	Huashan Hospital	2020-06-11	EARLY_PHASE1
NCT05246293	UNKNOWN	Rheumatoid Arthritis; Interstitial Lung Disease	National Institute of Respiratory Diseases, Mexico	2022-08-08	PHASE2
NCT06310057	COMPLETED	Axial Spondyloarthritis	Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh	2022-01-01	PHASE4
NCT05048238	COMPLETED	Cutaneous Lupus	National Institute of Allergy and Infectious Diseases (NIAID)	2022-09-30	PHASE1
NCT04768504	TERMINATED	Immune-Mediated Colitis	Khashayar Esfahani	2022-03-22	PHASE2
NCT06278402	COMPLETED	Alopecia Areata; Alopecia Totalis; Alopecia Universalis	Jinnah Hospital	2023-07-01	PHASE3
NCT04062695	UNKNOWN	Psoriatic Arthritis; Spondylitis; Sacroilitis	Charite University, Berlin, Germany	2020-08-04	PHASE2
NCT04925973	ACTIVE_NOT_RECRUITING	Ulcerative Colitis Acute	McMaster University	2021-06-01	PHASE2
NCT04311567	TERMINATED	Rheumatoid Arthritis; Interstitial Lung Disease Due to Systemic Disease (Disorder); RA; ILD	Vastra Gotaland Region	2020-11-07	PHASE4
NCT03755466	UNKNOWN	Rheumatoid Arthritis	Shinshu University	2018-11-21	PHASE2
NCT06202560	Enrolling by invitation	Frontal Fibrosing Alopecia\|Lichen Planopilaris	Institute of Dermatology Thailand	2023-11-29	Not Applicable
NCT04928066	COMPLETED	Arthritis, Rheumatoid	Qilu Hospital of Shandong University	2020-03-01	PHASE4
NCT05487963	COMPLETED	Atopic Dermatitis	CAGE Bio Inc.	2022-11-09	PHASE1; PHASE2
NCT05293119	UNKNOWN	Vitiligo; Effect of Drug	Pi Research Consultancy Center, Bangladesh	2022-05-30	EARLY_PHASE1
NCT03815578	COMPLETED	Rheumatoid Arthritis	University Hospital, Bordeaux	2019-06-17
NCT05400889	UNKNOWN	Idiopathic Inflammatory Myopathies	Peking University People's Hospital	2022-06-10	PHASE2
NCT06157905	COMPLETED	Extensive Alopecia Areata	Services Institute of Medical Sciences, Pakistan	2022-08-06	EARLY_PHASE1
NCT05165771	WITHDRAWN	Rheumatoid Arthritis	Gilead Sciences	2022-07	PHASE2
NCT05087589	UNKNOWN	Primary Sjögren's Syndrome	Peking University People's Hospital	2021-11-20	PHASE2
NCT04299971	UNKNOWN	Takayasu Arteritis; Methotrexate; Inhibition; Treatment	Shanghai Zhongshan Hospital	2020-03-01	PHASE4
NCT05133297	COMPLETED	Rheumatoid Arthritis	Hangzhou Highlightll Pharmaceutical Co., Ltd	2022-02-16	PHASE2
NCT04580277	TERMINATED	Pouchitis; Ileal Pouchitis; Ileal Pouch	Cedars-Sinai Medical Center	2021-01-25	PHASE2
NCT03288324	COMPLETED	Cutaneous Lupus; Systemic Lupus Erythematosus	Children's Hospital Medical Center, Cincinnati	2017-08-23	PHASE1; PHASE2
NCT05487703	Completed	Arthritis Rheumatoid	Pfizer	2022-11-14	--
NCT04927000	UNKNOWN	Rheumatoid Arthritis	Second Affiliated Hospital, Zhejiang University, School of Medicine	2021-05-31	PHASE4
NCT04141904	TERMINATED	Depression; Inflammation	University of Oxford	2020-02-10	PHASE1; PHASE2
NCT05082428	Completed	Ulcerative Colitis	Pfizer	2022-05-30	--
NCT05728008	Completed	Ulcerative Colitis	IRCCS San Raffaele	2022-04-05	--
NCT04799262	COMPLETED	Polymyalgia Rheumatica; Effect of Drug; Safety Issues	RenJi Hospital	2021-01-01	PHASE2
NCT04768504	Recruiting	Immune-Mediated Colitis	Khashayar Esfahani\|Sir Mortimer B. Davis - Jewish General Hospital	2022-03-22	Phase 2
NCT04413617	COMPLETED	Rheumatoid Arthritis	Pfizer	2020-07-29	PHASE2
NCT03970837	TERMINATED	Arthritis, Rheumatoid	GlaxoSmithKline	2019-06-05	PHASE3
NCT04985955	COMPLETED	Healthy	Janssen Research & Development, LLC	2021-07-30	PHASE1
NCT03980483	COMPLETED	Arthritis, Rheumatoid	GlaxoSmithKline	2019-05-16	PHASE3
NCT03910543	COMPLETED	Cutaneous Sarcoidosis; Granuloma Annulare	Yale University	2019-04-11	PHASE1
NCT03486457	COMPLETED	Psoriatic Arthritis	Pfizer	2018-08-10	PHASE3
NCT04415151	TERMINATED	COVID-19 Pneumonia	Yale University	2020-10-14	PHASE2
NCT04973033	COMPLETED	ANCA Associated Vasculitis; Drug Use; JAK-STAT Pathway Deregulation	Shanghai Zhongshan Hospital	2019-12-01
NCT03800979	COMPLETED	Alopecia Areata	Institute of Dermatology, Thailand	2019-01-12	PHASE4
NCT04469114	COMPLETED	Covid19	Hospital Israelita Albert Einstein	2020-09-16	PHASE3
NCT04552197	COMPLETED	Healthy	Janssen Research & Development, LLC	2020-09-02	PHASE1
NCT04468425	COMPLETED	Healthy Subjects	TWi Biotechnology, Inc.	2020-10-14	PHASE1
NCT04034238	COMPLETED	Neoplasms With Mesothelin Expression; Epithelioid Mesothelioma; Cholangiocarcinoma, Extrahepatic; Adenocarcinoma, Pancreatic	National Cancer Institute (NCI)	2019-08-29	PHASE1
NCT03002649	COMPLETED	Dermatomyositis	Johns Hopkins University	2017-01	PHASE1
NCT04412252	WITHDRAWN	COVID-19	Pfizer	2020-07-06	PHASE2
NCT04338711	COMPLETED	Healthy	Pfizer	2020-06-17	PHASE1
NCT04390061	UNKNOWN	Pneumonitis, Interstitial; COVID-19	Università Politecnica delle Marche	2020-06	PHASE2
NCT01470612	COMPLETED	Ulcerative Colitis	Pfizer	2012-10-01	PHASE3
NCT04750317	COMPLETED	COVID-19	I.M. Sechenov First Moscow State Medical University	2020-05-11	PHASE2
NCT04464642	UNKNOWN	Rheumatoid Arthritis	Dr. Mohammad Mamun Khan	2019-07-10	PHASE4
NCT02092467	COMPLETED	Arthritis, Rheumatoid	Pfizer	2014-03-14	PHASE4
NCT03793439	COMPLETED	Sarcoidosis, Pulmonary; Sarcoidosis Lung; Sarcoidosis	Oregon Health and Science University	2019-05-15	PHASE1
NCT04332042	UNKNOWN	SARS-COv2 Related Interstitial Pneumonia	Università Politecnica delle Marche	2020-04-10	PHASE2
NCT03159936	TERMINATED	Discoid Lupus Erythematosus; Systemic Lupus Erythematosus	Tufts Medical Center	2017-04-03	EARLY_PHASE1
NCT03281304	TERMINATED	Ulcerative Colitis	Pfizer	2017-11-16	PHASE4
NCT03598959	UNKNOWN	Extranodal NK/T-cell Lymphoma	Sichuan University	2019-01-01	PHASE2
NCT03502616	COMPLETED	Ankylosing Spondylitis	Pfizer	2018-06-07	PHASE3
NCT04111614	COMPLETED	Healthy	Pfizer	2019-10-11	PHASE1
NCT03580343	UNKNOWN	Uveitis; Scleritis	Washington University School of Medicine	2019-04-04	PHASE2
NCT03736161	COMPLETED	Psoriatic Arthritis	Globe Pharmaceuticals Limited	2017-09-15	PHASE3
NCT03016884	UNKNOWN	Herpes Zoster	HaEmek Medical Center, Israel	2017-01	PHASE4
NCT03504072	UNKNOWN	Spondyloarthritis	Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh	2018-01-16	PHASE4
NCT01976364	COMPLETED	Arthritis, Psoriatic	Pfizer	2014-02-17	PHASE3
NCT02592434	COMPLETED	Juvenile Idiopathic Arthritis	Pfizer	2016-06-10	PHASE3
NCT03274076	COMPLETED	Systemic Sclerosis; Scleroderma	University of Michigan	2017-09-25	PHASE1; PHASE2
NCT03868072	COMPLETED	Rheumatoid Arthritis	Chong Kun Dang Pharmaceutical	2019-02-22	PHASE1
NCT04403776	COMPLETED	Healthy	Pfizer	2018-12-03	PHASE1
NCT03738956	UNKNOWN	Axial Spondyloarthritis	Globe Pharmaceuticals Limited	2017-09-01	PHASE2; PHASE3
NCT02831855	COMPLETED	Rheumatoid Arthritis	Pfizer	2016-09-01	PHASE4
NCT02996500	COMPLETED	Rheumatoid Arthritis	Pfizer	2016-11-10	PHASE2
NCT02812342	COMPLETED	Alopecia Areata; Alopecia Totalis; Alopecia Universalis	Yale University	2016-09	PHASE2
NCT02535689	COMPLETED	Systemic Lupus Erythematosus	National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)	2015-08-28	PHASE1
NCT02299297	COMPLETED	Alopecia Areata	Columbia University	2015-01	PHASE2
NCT02566967	COMPLETED	Rheumatoid Arthritis	Norman B. Gaylis, MD	2015-05	PHASE3
NCT03112148	COMPLETED	Healthy	Pfizer	2017-09-11	PHASE1
NCT03103412	COMPLETED	Active Mild Ulcerative Colitis, Active Moderate Ulcerative Colitis, Healthy Subjects	Theravance Biopharma	2017-05-04	PHASE1
NCT02321930	COMPLETED	Rheumatoid Arthritis	University of California, Los Angeles	2016-02-16	PHASE4
NCT02281552	COMPLETED	Rheumatoid Arthritis	Pfizer	2014-11-18	PHASE3
NCT02187055	COMPLETED	Rhematoid Arthritis	Pfizer	2014-08	PHASE4
NCT00413699	COMPLETED	Arthritis, Rheumatoid	Pfizer	2007-02-05	PHASE3
NCT01470599	COMPLETED	Crohn's Disease	Pfizer	2012-04	PHASE2
NCT01163253	TERMINATED	Psoriasis	Pfizer	2010-09	PHASE3
NCT01458574	COMPLETED	Ulcerative Colitis	Pfizer	2012-07-20	PHASE3
NCT01882439	COMPLETED	Psoriatic Arthritis	Pfizer	2013-08	PHASE3
NCT01877668	COMPLETED	Psoriatic Arthritis	Pfizer	2014-01-20	PHASE3
NCT01513902	COMPLETED	Juvenile Idiopathic Arthritis	Pfizer	2013-03	PHASE1
NCT02312882	COMPLETED	Alopecia Areata; Alopecia Totalis; Alopecia Universalis	Stanford University	2014-12
NCT02197455	COMPLETED	Alopecia Areata (AA); Alopecia Totalis (AT); Alopecia Universalis (AU)	Yale University	2014-07	PHASE2
NCT02487433	COMPLETED	Healthy	Pfizer	2015-06	PHASE1
NCT01393899	COMPLETED	Crohn's Disease	Pfizer	2012-03	PHASE2
NCT01815424	COMPLETED	Psoriasis	Pfizer	2013-12	PHASE3
NCT02147587	COMPLETED	Rheumatoid Arthritis	Pfizer	2014-06	PHASE2
NCT01458951	COMPLETED	Ulcerative Colitis	Pfizer	2012-06	PHASE3
NCT01465763	COMPLETED	Ulcerative Colitis	Pfizer	2012-04	PHASE3
NCT01786668	COMPLETED	Ankylosing Spondylitis	Pfizer	2013-04	PHASE2
NCT00658359	COMPLETED	Kidney Transplantation	Pfizer	2008-08	PHASE2
NCT01393626	COMPLETED	Crohn's Disease	Pfizer	2011-10	PHASE2
NCT02193815	COMPLETED	Psoriasis Vulgaris	Pfizer	2014-09	PHASE1
NCT01831466	COMPLETED	Psoriasis Vulgaris; Psoriasis	Pfizer	2013-05	PHASE2
NCT02001181	COMPLETED	Dermatitis, Atopic	Pfizer	2013-12	PHASE2
NCT02084875	COMPLETED	Healthy	Pfizer	2014-04-11	PHASE1
NCT00263328	COMPLETED	Kidney Transplantation	Pfizer	2005-12	PHASE2
NCT01519089	COMPLETED	Psoriasis	Pfizer	2012-03	PHASE3
NCT01741493	COMPLETED	Rheumatoid Arthritis	AbbVie (prior sponsor, Abbott)	2012-11	PHASE1
NCT00661661	COMPLETED	Rheumatoid Arthritis	Pfizer	2008-04	PHASE3
NCT01164579	COMPLETED	Rheumatoid Arthritis	Pfizer	2010-10	PHASE2
NCT01710046	COMPLETED	Plaque Psoriasis	Pfizer	2013-03	PHASE2
NCT01276639	COMPLETED	Psoriasis	Pfizer	2011-03	PHASE3
NCT01309737	COMPLETED	Psoriasis	Pfizer	2011-03	PHASE3
NCT01039688	COMPLETED	Arthritis, Rheumatoid	Pfizer	2010-01	PHASE3
NCT01484561	COMPLETED	Arthritis, Rheumatoid	Pfizer	2012-04	PHASE1
NCT01186744	COMPLETED	Psoriasis	Pfizer	2010-09	PHASE3
NCT01241591	COMPLETED	Psoriasis	Pfizer	2010-11	PHASE3
NCT01731327	COMPLETED	Healthy	Pfizer	2012-11	PHASE1
NCT01226680	WITHDRAWN	Keratoconjunctivitis Sicca	Pfizer	2010-12-01	PHASE2
NCT01599377	COMPLETED	Healthy	Pfizer	2012-05	PHASE1
NCT01359150	COMPLETED	Rheumatoid Arthritis	Pfizer	2011-09	PHASE2
NCT01262118	COMPLETED	Rheumatoid Arthritis	Pfizer	2011-05	PHASE1
NCT01499004	COMPLETED	Healthy	Pfizer	2011-11	PHASE1
NCT00976599	COMPLETED	Rheumatoid Arthritis	Pfizer	2009-11	PHASE2
NCT00847613	COMPLETED	Arthritis, Rheumatoid	Pfizer	2009-03	PHASE3
NCT00853385	COMPLETED	Rheumatoid Arthritis	Pfizer	2009-05	PHASE3
NCT00960440	COMPLETED	Arthritis, Rheumatoid	Pfizer	2009-10	PHASE3
NCT00856544	COMPLETED	Arthritis, Rheumatoid	Pfizer	2009-05	PHASE3
NCT01059864	COMPLETED	Rheumatoid Arthritis	Pfizer	2010-02	PHASE2
NCT01101919	COMPLETED	Healthy	Pfizer	2010-10	PHASE1
NCT01204112	COMPLETED	Healthy	Pfizer	2010-09	PHASE1
NCT01184092	COMPLETED	Rheumatoid Arthritis	Pfizer	2010-08	PHASE1
NCT01184001	COMPLETED	Rheumatoid Arthritis	Pfizer	2010-09	PHASE1
NCT01202240	COMPLETED	Healthy	Pfizer	2010-09	PHASE1
NCT01143805	COMPLETED	Healthy	Pfizer	2010-07	PHASE1
NCT01185184	COMPLETED	Healthy	Pfizer	2010-08	PHASE1
NCT00687193	COMPLETED	Arthritis, Rheumatoid	Pfizer	2009-03	PHASE2
NCT01137708	COMPLETED	Healthy	Pfizer	2010-06	PHASE1
NCT00814307	COMPLETED	Arthritis, Rheumatoid	Pfizer	2009-02	PHASE3
NCT00483756	COMPLETED	Kidney Transplantation	Pfizer	2007-08	PHASE2
NCT00969813	COMPLETED	Hepatic Insufficiency	Pfizer	2009-11	PHASE1
NCT00784719	COMPLETED	Dry Eye Syndromes	Pfizer	2008-11	PHASE1; PHASE2
NCT00615199	COMPLETED	Crohn's Disease	Pfizer	2008-01	PHASE2
NCT00678210	COMPLETED	Psoriasis	Pfizer	2008-07	PHASE2
NCT00860496	COMPLETED	Healthy Volunteers	Pfizer	2009-06	PHASE1
NCT00678561	COMPLETED	Psoriasis	Pfizer	2008-10-13	PHASE2
NCT00902460	COMPLETED	Healthy Volunteer	Pfizer	2009-06	PHASE1
NCT00550446	COMPLETED	Arthritis, Rheumatoid	Pfizer	2007-09	PHASE2
NCT00603512	COMPLETED	Arthritis, Rheumatoid	Pfizer	2008-01	PHASE2
NCT00413660	COMPLETED	Arthritis, Rheumatoid	Pfizer	2007-01	PHASE2
NCT01743677	COMPLETED	Healthy	Pfizer	2007-10-26	PHASE1
NCT00106639	COMPLETED	Kidney Transplantation	Pfizer	2005-05	PHASE2
NCT00147498	COMPLETED	Rheumatoid Arthritis	Pfizer	2005-01	PHASE2
NCT01745055	COMPLETED	Rheumatoid Arthritis	Pfizer	2005-04	PHASE1
NCT01710033	COMPLETED	Kidney Transplant	Pfizer	2003-09	PHASE1
NCT01736696	COMPLETED	Psoriasis; Immunomodulation	Pfizer	2002-11	PHASE1
NCT01740362	COMPLETED	Renal Impairment	Pfizer	2003-10	PHASE1
NCT01710020	COMPLETED	End-Stage Renal Disease; Hemodialysis	Pfizer	2003-02	PHASE1
NCT00556257	WITHDRAWN	Kidney Transplantation	Pfizer	2007-08	PHASE2

(data from https://clinicaltrials.gov, updated on 2026-07-21)

Check the CP-690550 (Tofacitinib) Citrate product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Compliance for Clinical Use

Mechanism and Biochemical Profile

CP-690550 (Tofacitinib) citrate selectively binds to Janus kinase enzymes, primarily inhibiting JAK3, JAK2, and JAK1 to block downstream cytokine receptor phosphorylation and signal transduction. Consequently, this target blockade suppresses signal transducer and activator of transcription activation, diminishing pro-inflammatory gene expression and immune cell proliferation to mitigate pathology in autoimmune conditions such as rheumatoid arthritis, ulcerative colitis, and alopecia areata.

Appendix RUO and cGMP Quality Standards

Quality Dimension	RUO (Research Use Only)	cGMP (Current Good Manufacturing Practice)
Clinical Applicability	Prohibited in human clinical trials or medical diagnostics.	Mandatory for human clinical trials (Phase I–III) and therapies.
Regulatory Status	Non-regulated grade; exempt from drug manufacturing laws.	Legally enforced by health authorities (e.g., FDA, EMA, NMPA).
Facility Environment	Unclassified analytical or research laboratories.	Validated Cleanrooms (ISO Class 5–8) with continuous monitoring.
Quality Control	Basic purity and activity testing.	Rigorous safety release testing (Sterility, Endotoxin, Mycoplasma).
Process Validation	Basic equipment calibration; no process validation required.	Full qualification (IQ/OQ/PQ) and complete batch records.
Quality Assurance	Vendor self-declared without required formal QMS.	Mandatory QA/QC unit, Change Control, CAPA, and vendor audits.
Regulatory Impact	High risk of IND rejection if used as a critical raw material.	Required for IND/NDA filings, supported by Drug Master Files (DMF).

Footnotes

Regulatory Note: Governed by FDA (21 CFR Parts 210/211/312), EMA (EudraLex Vol 4), ICH Guidelines (E6/Q7/Q9/Q10), and compendial standards (USP <71>/<85>/<1043>).