CAS No. 483-90-9

Batch: Purity:99.66
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Toddalolactone Chemical Structure
Chemical Structure
Check the Toddalolactone product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 6-[(2R)-2,3-dihydroxy-3-methylbutyl]-5,7-dimethoxychromen-2-one
CAS Number 483-90-9
Molecular Formula

C16H20O6
Molecular Weight (MW) 308.33
SMILES CC(C)(C(CC1=C(C=C2C(=C1OC)C=CC(=O)O2)OC)O)O
InChIKey GLWPLQBQHWYKRK-CYBMUJFWSA-N

Biological Activity

Toddalolactone is a natural coumarin derivative that functions as an inhibitor of plasminogen activator inhibitor-1 (PAI-1). By targeting PAI-1, it modulates the plasminogen activator pathway and prevents PAI-1 from suppressing tissue-type plasminogen activator (tPA) and urokinase-type plasminogen activator (uPA). This interference promotes plasmin generation, leading to altered fibrinolytic activity, extracellular matrix degradation, and attenuated cellular migration phenotypes.

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 61 mg/mL (197.83 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.