CAS No. 9002-96-4
Batch:
Purity:98
Chemical Structure
Check the
Tocofersolan
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| CAS Number | 9002-96-4 | |
|---|---|---|
| Molecular Formula |
(C2H4O)nC33H54O5 |
|
| Molecular Weight (MW) | 1513 | |
| SMILES | CC1=C(C(=C(C2=C1OC(CC2)(C)CCCC(C)CCCC(C)CCCC(C)C)C)OC(=O)CCC(=O)OCCOCCOCCO)C |
Biological Activity
Tocofersolan is a synthetic, water-soluble derivative of vitamin E that acts as a P-glycoprotein inhibitor and amphiphilic delivery agent. It inhibits P-glycoprotein-mediated efflux transport to enhance cellular accumulation and oral bioavailability of hydrophobic molecules. Additionally, Tocofersolan serves as a bioavailable source of d-alpha-tocopherol, protecting cellular membranes against lipid peroxidation and mitigating oxidative stress. [1]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
100 mg/mL
(66.09 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 2 mg/mL (Warmed with 50℃ water bath; Ultrasonicated) |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Reference
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Note: Technical data last updated: Sep 1, 2026.