CAS No. 2760481-53-4

Batch: Purity:99.92
Check CoA
TNG908 (Ralometostat) Chemical Structure
Chemical Structure
Check the TNG908 (Ralometostat) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name N-(6-amino-5-methyl-3-pyridinyl)-2-[(2R,5S)-2-(1,3-benzothiazol-5-yl)-5-methylpiperidin-1-yl]-2-oxoacetamide
CAS Number 2760481-53-4
Molecular Formula

C21H23N5O2S
Molecular Weight (MW) 409.51
InChIKey NXXBDYHMHHINFC-YVEFUNNKSA-N

Ordering Information

Biological Activity

Ralometostat (TNG908) is a potent, selective, and brain-penetrant inhibitor of protein arginine methyltransferase 5 (PRMT5) that acts through an MTA-cooperative binding mechanism. By targeting the PRMT5-MTA complex in MTAP-deleted cancers with elevated methylthioadenosine levels, it inhibits downstream arginine methylation pathways to induce synthetic lethality in MTAP-null tumor cells and demonstrate selective antitumor efficacy in mouse xenograft models. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
🧮 Molarity Calculator

Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 82 mg/mL (200.23 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 2 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Jump to

Note: Technical data last updated: Sep 1, 2026.