TNG-462 (Vopimetostat) is a potent, selective, and MTA-cooperative PRMT5 inhibitor. It affects PRMT5-mediated epigenetic signaling by binding to the PRMT5-MTA complex to block methyltransferase activity, effectively inhibiting tumor cell proliferation in MTAP-deleted cancers.
TNG-462 (Vopimetostat) IC50 for Cell-based and Cell-free Assays
Comprehensive IC50 Values for TNG-462 (Vopimetostat) Across Cell-free Enzyme Inhibitory Profiles and Cell-based Functional Assays.