CAS No. 1422171-08-1
Batch:
Purity:99.65
Chemical Structure
Check the
TMP778
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | 2-[2-[(S)-(3,5-dimethyl-1,2-oxazol-4-yl)-hydroxymethyl]-1-benzofuran-5-yl]-N-[(S)-(2,4-dimethylphenyl)-phenylmethyl]acetamide | |
|---|---|---|
| CAS Number | 1422171-08-1 | |
| Molecular Formula |
C31H30N2O4 |
|
| Molecular Weight (MW) | 494.58 | |
| InChIKey | DIURRJOJDQOMFC-IOWSJCHKSA-N |
Biological Activity
TMP778 is a selective inhibitor targeting retinoic acid receptor-related orphan receptor gamma t (RORγt), a key lineage-defining nuclear receptor transcription factor. By suppressing RORγt transcriptional activity, it attenuates T helper 17 (Th17) cell differentiation and downstream expression of proinflammatory cytokines such as IL-17. This targeted pathway inhibition effectively disrupts Th17-mediated inflammatory cascades, offering a potential therapeutic strategy for suppressing autoimmune disease phenotypes. [1][2]
How to Prepare Stock Solution?
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Concentration
Volume
Mass
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Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
99 mg/mL
(200.16 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 99 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Reference
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Note: Technical data last updated: Sep 1, 2026.