CAS No. 1186372-20-2
Batch:
Purity:99.69
Chemical Structure
Check the
TMN355
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 2-chloro-N-(9H-fluoren-9-ylcarbamoyl)-6-fluorobenzamide | |
|---|---|---|
| CAS Number | 1186372-20-2 | |
| Molecular Formula |
C21H14ClFN2O2 |
|
| Molecular Weight (MW) | 380.80 | |
| SMILES | C1=CC=C2C(=C1)C(C3=CC=CC=C32)NC(=O)NC(=O)C4=C(C=CC=C4Cl)F | |
| InChIKey | SFNLLCUAISZNRV-UHFFFAOYSA-N |
TMN355 is a potent inhibitor of cyclophilin A (CypA) that targets peptidyl-prolyl cis-trans isomerase activity. By blocking CypA-mediated inflammatory signaling, TMN355 reduces foam cell formation and suppresses pro-inflammatory cytokine secretion. This target inhibition attenuates vascular extracellular matrix remodeling and inflammatory responses in macrophages, providing therapeutic potential against the progression of atherosclerosis and related cardiovascular disorders. [1]
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
76 mg/mL
(199.57 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.