CAS No. 1103926-82-4
Batch:
Purity:99.57
Chemical Structure
Check the
TM5275 Sodium
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | sodium 2-[[2-[2-(4-benzhydrylpiperazin-1-yl)-2-oxoethoxy]acetyl]amino]-5-chlorobenzoate | |
|---|---|---|
| CAS Number | 1103926-82-4 | |
| Molecular Formula |
C28H27ClN3NaO5 |
|
| Molecular Weight (MW) | 543.97 | |
| SMILES | C1CN(CCN1C(C2=CC=CC=C2)C3=CC=CC=C3)C(=O)COCC(=O)NC4=C(C=C(C=C4)Cl)C(=O)[O-].[Na+] | |
| InChIKey | JSHSGBIWNPQCQZ-UHFFFAOYSA-M |
TM5275 Sodium is an orally bioavailable plasminogen activator inhibitor-1 (PAI-1) inhibitor with an IC50 of 6.95 μM. By selective inhibition of PAI-1, it prevents PAI-1 from binding to tissue plasminogen activator (tPA), thereby enhancing endogenous fibrinolysis and suppressing thrombus formation. In preclinical models, TM5275 displays antithrombotic activity without increasing bleeding risk or disrupting systemic coagulation parameters.
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
100 mg/mL
(183.83 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.