Home Immunology & Inflammation Complement System TLQP-21 TFA For research use only.

TLQP-21 TFA

Synonyms:

LQP-21 TFA (TLQP-21 Trifluoroacetate) is a VGF-derived peptide that activates the C3aR1 receptor through a folding-upon-binding mechanism.

TLQP-21 TFA Chemical Structure

TLQP-21 TFA Chemical Structure

CAS: 869988-94-3(free base)

Purity & Quality Control

Batch: Purity: 99.90%
99.90

TLQP-21 TFA Related Products

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Biological Activity

Description LQP-21 TFA (TLQP-21 Trifluoroacetate) is a VGF-derived peptide that activates the C3aR1 receptor through a folding-upon-binding mechanism.
Targets
C3aR1 receptor [1]
In vitro
In vitro

TLQP-21 activates the cognate C3aR1 receptor leading to enhanced lipolysis in adipocytes and arginine 21 is essential for TLQP-21 lipolysis in 3T3L1 adipocytes.[1]
Cell Research Cell lines 3T3L1 adipocytes
Concentrations 100 nM
Incubation Time 3 h
Method

3T3-L1 adipocytes differentiated on 6-well plates are first starved for 3 hours in KRH with 1% BSA, then incubate with TLQP-21 in the presence and absence of specific agonists/antagonists, suspended in KRH with 4% BSA. Following 3 hours of incubation at 37°C and 5% CO2, the media is collected and incubated at 60°C for 20 min to inactivate any residual enzymatic reaction activity. The cells are gathered for protein concentration or trypsinized for cell diameter and viability measurements.

Chemical Information & Solubility

Molecular Weight 2546.75 Formula

C107H170N40O26(TFA)
CAS No. 869988-94-3(free base) SDF --
Density 95.0~105.0%
Smiles N/A
Storage (From the date of receipt) 3 years-20°C powder

In vitro
Batch:

DMSO : 100 mg/mL ( (39.26 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 100 mg/mL

Ethanol : 100 mg/mL


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In vivo
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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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