CAS No. 1903783-48-1
| IUPAC Name | 4,7-dichloro-3-[2-(4-cyclopropylphenyl)-2-oxoethyl]-3-hydroxy-1H-indol-2-one | |
|---|---|---|
| CAS Number | 1903783-48-1 | |
| Molecular Formula |
C19H15Cl2NO3 |
|
| Molecular Weight (MW) | 376.23 | |
| SMILES | OC1(CC(=O)C2=CC=C(C=C2)C3CC3)C(=O)NC4=C(Cl)C=CC(=C14)Cl | |
| InChIKey | ZWHNLSHDLKIXOG-UHFFFAOYSA-N |
TK216 is a potent inhibitor targeting E26 transformation-specific (ETS) family transcription factors that functions by blocking their protein-protein interaction with RNA helicase A (RHA). By preventing the assembly of the functional ETS-RHA complex, TK216 impairs ETS-mediated transcriptional activation and downregulates downstream oncogenic signaling networks. Consequently, this target engagement suppresses tumor cell proliferation and triggers apoptosis, demonstrating significant antilymphoma activity. [1]
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Concentration
Volume
Mass
|
|---|
| Solvent | Solubility & Note |
|---|---|
| DMSO |
75 mg/mL
(199.34 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 50 mg/mL |
| Water | Insoluble |
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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