CAS No. 393105-53-8
Batch:
Purity:99.71
Chemical Structure
Check the
Tiplaxtinin (PAI-039)
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 2-[1-benzyl-5-[4-(trifluoromethoxy)phenyl]indol-3-yl]-2-oxoacetic acid | |
|---|---|---|
| CAS Number | 393105-53-8 | |
| Molecular Formula |
C24H16F3NO4 |
|
| Molecular Weight (MW) | 439.38 | |
| SMILES | C1=CC=C(C=C1)CN2C=C(C3=C2C=CC(=C3)C4=CC=C(C=C4)OC(F)(F)F)C(=O)C(=O)O | |
| InChIKey | ODXQFEWQSHNQNI-UHFFFAOYSA-N |
Tiplaxtinin (PAI-039) is a potent, orally active, and selective plasminogen activator inhibitor-1 (PAI-1) inhibitor with an IC50 value of. By inhibiting PAI-1 activity, it blocks the inhibition of tissue plasminogen activator (tPA) and urokinase plasminogen activator (uPA), thereby enhancing plasmin-mediated fibrinolysis and promoting extracellular matrix remodeling and thrombus clearance across various vascular disease models. [1]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
88 mg/mL
(200.28 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 7 mg/mL |
| Water | Insoluble |
| DMSO |
88 mg/mL
(200.28 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 22 mg/mL |
| Water | Insoluble |
| DMSO |
88 mg/mL
(200.28 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 22 mg/mL |
| Water | Insoluble |
| DMSO |
72 mg/mL
(163.86 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 18 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
Looking for a specific aliquot size? Reach out to your local sales representative or contact us at orders@selleckchem.com.
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- Tiplaxtinin (PAI-039) Working Concentration | Cell Culture | Treatment
- Tiplaxtinin (PAI-039) Solubility in DMSO
- Tiplaxtinin (PAI-039) Stock Solution
- Tiplaxtinin (PAI-039) Storage
- Tiplaxtinin (PAI-039) Stability
- Tiplaxtinin (PAI-039) Combination Database
- Tiplaxtinin (PAI-039) Molecular Weight
- Tiplaxtinin (PAI-039) SMILES
- Tiplaxtinin (PAI-039) Chemical Structure (2D and 3D)
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- Tiplaxtinin (PAI-039) SDS｜MSDS
Note: Technical data last updated: Sep 1, 2026.