CAS No. 183204-74-2

Batch: Purity:98.62
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Tipiracil Chemical Structure Tipiracil Chemical Structure
Chemical Structure
Check the Tipiracil product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 5-chloro-6-[(2-iminopyrrolidin-1-yl)methyl]-1H-pyrimidine-2,4-dione
CAS Number 183204-74-2
Molecular Formula

C9H11ClN4O2
Molecular Weight (MW) 242.66
InChIKey QQHMKNYGKVVGCZ-UHFFFAOYSA-N

Biological Activity

Tipiracil is a potent inhibitor of thymidine phosphorylase (TPase). By inhibiting TPase activity, tipiracil blocks the enzymatic degradation of thymidine analogs such as trifluridine, thereby increasing their systemic exposure and intracellular accumulation. This inhibition prevents rapid drug inactivation and enhances phosphorylation into cytotoxic triphosphate metabolites, ultimately leading to DNA damage, inhibition of DNA synthesis, and suppression of tumor cell proliferation.

How to Prepare Stock Solution?

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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
Ethanol 3 mg/mL
Water 2 mg/mL
DMSO Insoluble
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.