CAS No. 183204-72-0

Batch: Purity:99.91
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Tipiracil hydrochloride Chemical Structure
Chemical Structure
Check the Tipiracil hydrochloride product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 5-chloro-6-[(2-iminopyrrolidin-1-yl)methyl]-1H-pyrimidine-2,4-dione;hydrochloride
CAS Number 183204-72-0
Molecular Formula

C9H11ClN4O2.HCl
Molecular Weight (MW) 279.12
SMILES C1CC(=N)N(C1)CC2=C(C(=O)NC(=O)N2)Cl.Cl
InChIKey KGHYQYACJRXCAT-UHFFFAOYSA-N

Biological Activity

Tipiracil hydrochloride is a potent inhibitor of thymidine phosphorylase that prevents the enzymatic degradation of trifluridine. By inhibiting thymidine phosphorylase, tipiracil prevents the inactivation of trifluridine, significantly increasing its systemic concentration and oral bioavailability. This sustained exposure enhances trifluridine phosphorylation, leading to increased DNA incorporation, double-strand DNA breakage, and suppression of cell growth in preclinical cancer models. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
Water 56 mg/mL
DMSO 16 mg/mL (57.32 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Reference

[1] Emura T, et al. Int J Oncol. 2005;27(2):449-55.

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Note: Technical data last updated: Sep 1, 2026.