Tipifarnib S enantiomer

For research use only.

Catalog No.S0404 Synonyms: (S)-(-)-R-115777,IND-58359 S enantiomer

CAS No. 192185-71-0

Tipifarnib S enantiomer ((S)-(-)-R-115777,IND-58359 S enantiomer) is the S-enantiomer of Tipifarnib. Tipifarnib is a potent and specific inhibitor of farnesyltransferase (FTase) with IC50 of 0.6 nM. Tipifarnib S enantiomer is the less active isomer.

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Biological Activity

Description Tipifarnib S enantiomer ((S)-(-)-R-115777,IND-58359 S enantiomer) is the S-enantiomer of Tipifarnib. Tipifarnib is a potent and specific inhibitor of farnesyltransferase (FTase) with IC50 of 0.6 nM. Tipifarnib S enantiomer is the less active isomer.

Protocol

References

Solubility (25°C)

Chemical Information

Molecular Weight
Formula
CAS No. 192185-71-0
Storage powder
in solvent
Synonyms (S)-(-)-R-115777,IND-58359 S enantiomer
Smiles CN1C=NC=C1C(C2=CC=C(C=C2)Cl)(C3=CC4=C(C=C3)N(C(=O)C=C4C5=CC(=CC=C5)Cl)C)N

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT00005832 Completed Drug: R115777 Pancreatic Cancer Southwest Oncology Group|National Cancer Institute (NCI) June 2000 Phase 2
NCT00005833 Completed Drug: R115777 Colorectal Cancer Southwest Oncology Group|National Cancer Institute (NCI) June 2000 Phase 2

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID