CAS No. 192185-72-1

Batch: Purity:99.88
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Tipifarnib (IND 58359) Chemical Structure
Chemical Structure
Check the Tipifarnib (IND 58359) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 6-[(R)-amino-(4-chlorophenyl)-(3-methylimidazol-4-yl)methyl]-4-(3-chlorophenyl)-1-methylquinolin-2-one
CAS Number 192185-72-1
Molecular Formula

C27H22Cl2N4O
Molecular Weight (MW) 489.4
SMILES CN1C=NC=C1C(C2=CC=C(C=C2)Cl)(C3=CC4=C(C=C3)N(C(=O)C=C4C5=CC(=CC=C5)Cl)C)N
InChIKey PLHJCIYEEKOWNM-HHHXNRCGSA-N

Ordering Information

Biological Activity

Tipifarnib is a potent, nonpeptidomimetic farnesyltransferase inhibitor with an IC50 of. By preventing the farnesylation of key cellular target proteins, it blocks Ras-mediated signal transduction pathways. This enzymatic inhibition significantly suppresses cell growth, induces apoptosis, and attenuates tumor angiogenesis, demonstrating particularly pronounced antiproliferative effects in tumor cells harboring H-Ras or N-Ras mutations. [1]

How to Prepare Stock Solution?

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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 14 mg/mL (28.6 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 9 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.