CAS No. 2230490-29-4
Batch:
Purity:99.07
Chemical Structure
Check the
Tinengotinib
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 4-[9-(2-chlorophenyl)-6-methyl-2,4,5,8,12-pentazatricyclo[8.4.0.03,7]tetradeca-1(14),3,6,8,10,12-hexaen-13-yl]morpholine | |
|---|---|---|
| CAS Number | 2230490-29-4 | |
| Molecular Formula |
C20H19ClN6O |
|
| Molecular Weight (MW) | 394.86 | |
| InChIKey | DQFCVOOFMXEPOC-UHFFFAOYSA-N |
Tinengotinib (TT-00420) is a multi-kinase inhibitor that strongly inhibits Aurora A and Aurora B, while also suppressing FGFR1/2/3, VEGFR1, JAK1/2, and CSF1R. By targeting mitotic progression and tumor microenvironment pathways, it inhibits cell proliferation and downregulates genes essential for growth in triple-negative breast cancer. Furthermore, tinengotinib upregulates CXCL10 and CXCL11 expression and reduces tumor-associated macrophage infiltration. [1]
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
79 mg/mL
(200.07 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.