CAS No. 27591-69-1

Batch: Purity:99.96
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Tilorone dihydrochloride Chemical Structure
Chemical Structure
Check the Tilorone dihydrochloride product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 2,7-bis[2-(diethylamino)ethoxy]fluoren-9-one;dihydrochloride
CAS Number 27591-69-1
Molecular Formula

C25H34N2O3.2HCl
Molecular Weight (MW) 483.47
SMILES CCN(CC)CCOC1=CC2=C(C=C1)C3=C(C2=O)C=C(C=C3)OCCN(CC)CC.Cl.Cl
InChIKey BSVYJQAWONIOOU-UHFFFAOYSA-N

Biological Activity

Tilorone dihydrochloride is an orally active, broad-spectrum antiviral agent that acts primarily as an inducer of endogenous interferon production. By activating alpha and beta interferon synthesis, it triggers innate immune pathways to inhibit viral replication across diverse viral families. Additionally, Tilorone dihydrochloride exhibits marked anti-inflammatory and antitumor properties through the modulation of immune responses and downstream cellular signaling cascades. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
Water 96 mg/mL
Ethanol 96 mg/mL
DMSO 43 mg/mL (88.94 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Reference

[1] Science. 1970;168(3939).

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Note: Technical data last updated: Sep 1, 2026.