CAS No. 137330-13-3
Batch:
Purity:99.24
Chemical Structure
Check the
Tilmicosin phosphate
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| CAS Number | 137330-13-3 | |
|---|---|---|
| Molecular Formula |
C46 H80 N2 O13 . H3 O4 P |
|
| Molecular Weight (MW) | 967.13 | |
| SMILES | CCC1C(C=C(C=CC(=O)C(CC(C(C(C(CC(=O)O1)O)C)OC2C(C(C(C(O2)C)O)N(C)C)O)CCN3CC(CC(C3)C)C)C)C)COC4C(C(C(C(O4)C)O)OC)OC.OP(=O)(O)O |
Biological Activity
Tilmicosin phosphate is a semi-synthetic macrolide antibiotic that targets the bacterial 50S ribosomal subunit. By binding to the 50S subunit within the ribosomal peptidyl transferase center, it inhibits bacterial protein synthesis by blocking nascent peptide chain elongation. This disruption of protein translation halts bacterial replication and growth, demonstrating antibacterial activity against key respiratory pathogens including Mannheimia haemolytica and Pasteurella multocida. [1]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
100 mg/mL
(103.39 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 100 mg/mL |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Reference
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Note: Technical data last updated: Sep 1, 2026.