CAS No. 77-60-1
Batch:
Purity:98
Chemical Structure
Check the
Tigogenin
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| CAS Number | 77-60-1 | |
|---|---|---|
| Molecular Formula |
C27H44O3 |
|
| Molecular Weight (MW) | 416.64 | |
| SMILES | CC1CCC2(C(C3C(O2)CC4C3(CCC5C4CCC6C5(CCC(C6)O)C)C)C)OC1 |
Biological Activity
Tigogenin is a steroidal sapogenin that exerts protective effects on bone tissue and functions as a precursor for steroid synthesis. It modulates bone remodeling pathways by promoting osteoblast differentiation and inhibiting osteoclastogenesis, thereby preventing bone loss and maintaining bone mineral density. Additionally, tigogenin regulates lipid homeostasis pathways, reducing intestinal cholesterol absorption and systemic lipid levels. [1]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| 4-Methylpyridine | 25 mg/mL |
| DMSO |
Insoluble
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.) |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Reference
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Note: Technical data last updated: Sep 1, 2026.