CAS No. 41276-02-2
| IUPAC Name | 11-benzyl-2-[(2-methylphenyl)methyl]-2,4,7,11-tetrazatricyclo[7.4.0.03,7]trideca-1(9),3-dien-8-one | |
|---|---|---|
| CAS Number | 41276-02-2 | |
| Molecular Formula |
C24H26N4O |
|
| Molecular Weight (MW) | 386.49 | |
| SMILES | CC1=CC=CC=C1CN2C3=C(CN(CC3)CC4=CC=CC=C4)C(=O)N5C2=NCC5 | |
| InChIKey | RSAQARAFWMUYLL-UHFFFAOYSA-N |
TIC10 Analogue is an orally bioavailable small-molecule compound that inactivates Akt and ERK signaling pathways, leading to the nuclear translocation of Foxo3a and subsequent upregulation of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL). Downstream induction of TRAIL triggers apoptosis in cancer cells, demonstrating enhanced metabolic stability, favorable pharmacokinetics, and the capability to cross the blood-brain barrier for oncology applications. [1]
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Concentration
Volume
Mass
|
|---|
| Solvent | Solubility & Note |
|---|---|
| DMSO |
11 mg/mL
(28.46 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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