CAS No. 1604810-83-4
Batch:
Purity:96.12
Chemical Structure
Check the
THZ1
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | N-[3-[[5-chloro-4-(1H-indol-3-yl)pyrimidin-2-yl]amino]phenyl]-4-[[(E)-4-(dimethylamino)but-2-enoyl]amino]benzamide | |
|---|---|---|
| CAS Number | 1604810-83-4 | |
| Molecular Formula |
C31H28ClN7O2 |
|
| Molecular Weight (MW) | 566.05 | |
| InChIKey | OBJNFLYHUXWUPF-IZZDOVSWSA-N |
THZ1 is a covalent cyclin-dependent kinase inhibitor targeting CDK7 alongside CDKand CDKBy covalently modifying a cysteine residue outside the canonical kinase domain, it disrupts transcriptional initiation and elongation, suppresses RNA polymerase II phosphorylation, and downregulates MYC expression. Consequently, THZ1 impairs super-enhancer-driven gene networks and exhibits potent antiproliferative effects across diverse malignancies, including human T-cell acute lymphoblastic leukemia. [1]
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
100 mg/mL
(176.66 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.