CAS No. 2058075-45-7
Batch:
Purity:98.10
Chemical Structure
Check the
THZ-P1-2
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| CAS Number | 2058075-45-7 | |
|---|---|---|
| Molecular Formula |
C31H29N7O2 |
|
| Molecular Weight (MW) | 531.61 |
THZ-P1-2 is a covalent inhibitor of phosphatidylinositol 5-phosphate 4-kinase (PI5P4K), targeting cysteines on a disordered loop of PI5P4Kα, PI5P4Kβ, and PI5P4Kγ to inhibit PI5P4Kα kinase activity. Target inhibition of the PI5P4K lipid kinase pathway disrupts cellular autophagic flux, resulting in impaired autophagosome clearance and increased nuclear localization of transcription factor EB (TFEB).
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
10 mg/mL
(18.81 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.