CAS No. 130-61-0

Batch: Purity:99.96
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Thioridazine hydrochloride Chemical Structure
Chemical Structure
Check the Thioridazine hydrochloride product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 10-[2-(1-methylpiperidin-2-yl)ethyl]-2-methylsulfanylphenothiazine;hydrochloride
CAS Number 130-61-0
Molecular Formula

C21H26N2S2.HCl
Molecular Weight (MW) 407.04
SMILES CN1CCCCC1CCN2C3=CC=CC=C3SC4=C2C=C(C=C4)SC.Cl
InChIKey NZFNXWQNBYZDAQ-UHFFFAOYSA-N

Ordering Information

Biological Activity

Thioridazine hydrochloride is a potent dopamine receptor antagonist with marked antipsychotic and antineoplastic activities. By selectively targeting dopamine receptors, particularly DRD2, it inhibits downstream signaling pathways including the PI3K/AKT and ERK cascades. This blockade selectively eliminates leukemic and solid tumor cancer stem cells by impairing their self-renewal capacity, inducing cell differentiation, and triggering cell death. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.