CAS No. 1226056-71-8

Batch: Purity:99.85
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Thiazovivin (TZV) Chemical Structure
Chemical Structure
Check the Thiazovivin (TZV) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name N-benzyl-2-(pyrimidin-4-ylamino)-1,3-thiazole-4-carboxamide
CAS Number 1226056-71-8
Molecular Formula

C15H13N5OS
Molecular Weight (MW) 311.36
SMILES C1=CC=C(C=C1)CNC(=O)C2=CSC(=N2)NC3=NC=NC=C3
InChIKey DOBKQCZBPPCLEG-UHFFFAOYSA-N

Ordering Information

Biological Activity

Thiazovivin is a potent, selective inhibitor of Rho-associated coiled-coil kinase (ROCK) that enhances the survival of human embryonic stem cells upon single-cell dissociation. By blocking ROCK signaling, thiazovivin stabilizes cell-surface E-cadherin and regulates cell adhesion, thereby preventing dissociation-induced apoptosis. Furthermore, when combined with TGF-β receptor inhibitor SB-431542 and MEK inhibitor PD-0325901, thiazovivin significantly increases the efficiency of somatic cell reprogramming to pluripotency. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 63 mg/mL (202.33 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.