CAS No. 154-87-0

Batch: Purity:99.95
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Thiamine pyrophosphate hydrochloride Chemical Structure
Chemical Structure
Check the Thiamine pyrophosphate hydrochloride product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

CAS Number 154-87-0
Molecular Formula

C12H19ClN4O7P2S
Molecular Weight (MW) 460.77
SMILES CC1=C(SC=[N+]1CC2=CN=C(N=C2N)C)CCOP(=O)(O)OP(=O)(O)O.[Cl-]

Ordering Information

Biological Activity

Thiamine pyrophosphate hydrochloride is an essential thiamine derivative that acts as a coenzyme for multiple enzymes involved in primary metabolism, including pyruvate dehydrogenase, alpha-ketoglutarate dehydrogenase, and transketolase. By facilitating critical enzymatic decarboxylation and transfer reactions, it plays a vital role in cellular energy production, carbohydrate catabolism, and the pentose phosphate pathway to support fundamental metabolic homeostasis. [1]

How to Prepare Stock Solution?

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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
Water 92 mg/mL
DMSO Insoluble
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.