CAS No. 1009816-48-1

Batch: Purity:99.99
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Thiamet G Chemical Structure
Chemical Structure
Check the Thiamet G product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name (3aR,5R,6S,7R,7aR)-2-ethylimino-5-(hydroxymethyl)-1,3a,5,6,7,7a-hexahydropyrano[3,2-d][1,3]thiazole-6,7-diol
CAS Number 1009816-48-1
Molecular Formula

C9H16N2O4S
Molecular Weight (MW) 248.3
SMILES CCN=C1NC2C(C(C(OC2S1)CO)O)O
InChIKey PPAIMZHKIXDJRN-FMDGEEDCSA-N

Ordering Information

Biological Activity

Thiamet G is a potent and selective O-GlcNAcase (OGA) inhibitor with a Ki of 21 nM, displaying 37,000-fold selectivity over human lysosomal beta-hexosaminidase. By blocking OGA activity, Thiamet G increases cellular levels of protein O-GlcNAcylation and decreases hyperphosphorylation of tau protein in neuronal models. This inhibition helps modulate protein homeostasis and maintain cellular stability within central nervous system pathways. [1]

How to Prepare Stock Solution?

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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 50 mg/mL (201.36 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water 50 mg/mL
Ethanol 6 mg/mL
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.