CAS No. 67526-95-8

Batch: Purity:99.86
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Thapsigargin Chemical Structure
Chemical Structure
Check the Thapsigargin product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name [(3S,3aR,4S,6S,6aR,7S,8S,9bS)-6-acetyloxy-4-butanoyloxy-3,3a-dihydroxy-3,6,9-trimethyl-8-[(Z)-2-methylbut-2-enoyl]oxy-2-oxo-4,5,6a,7,8,9b-hexahydroazuleno[4,5-b]furan-7-yl] octanoate
CAS Number 67526-95-8
Molecular Formula

C34H50O12
Molecular Weight (MW) 650.75
InChIKey IXFPJGBNCFXKPI-FSIHEZPISA-N

Ordering Information

Biological Activity

Thapsigargin is a potent, non-competitive inhibitor of sarco/endoplasmic reticulum Ca2+-ATPase (SERCA). By selectively inhibiting SERCA pumps, it disrupts intracellular calcium homeostasis and rapidly depletes endoplasmic reticulum calcium stores. This sustained elevation of cytosolic calcium concentrations triggers endoplasmic reticulum stress and activates unfolded protein response pathways, ultimately driving cell apoptosis in various cell lines. [1]

How to Prepare Stock Solution?

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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 100 mg/mL (153.66 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 100 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.