CAS No. 2412056-27-8

Batch: Purity:98.45
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Thalidomide-5-NH2-CH2-COOH Chemical Structure
Chemical Structure
Check the Thalidomide-5-NH2-CH2-COOH product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 2-[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-5-yl]amino]acetic acid
CAS Number 2412056-27-8
Molecular Formula

C15H13N3O6
Molecular Weight (MW) 331.28
SMILES OC(=O)CNC1=CC=C2C(=O)N(C3CCC(=O)NC3=O)C(=O)C2=C1
InChIKey ZATMCTCUKSYXHM-UHFFFAOYSA-N

Ordering Information

Biological Activity

Thalidomide-5-NH2-CH2-COOH is a potent and selective inhibitor of tropomyosin receptor kinase (Trk) [1]. By targeting tropomyosin receptor kinase, it modulates downstream signaling through pathways such as MAPK, impairing cellular proliferation and survival mechanisms [1]. Additionally, as a functionalized thalidomide derivative, it acts as a recruitment ligand for the cereblon E3 ubiquitin ligase complex in targeted protein degradation applications [2].[1][2]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 66 mg/mL (199.22 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.