CAS No. 2139287-33-3

Batch: Purity:99.30
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THAL-SNS-032 Chemical Structure
Chemical Structure
Check the THAL-SNS-032 product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name N-[5-[(5-tert-butyl-1,3-oxazol-2-yl)methylsulfanyl]-1,3-thiazol-2-yl]-1-[2-[2-[2-[2-[2-[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]amino]ethoxy]ethoxy]ethoxy]ethylamino]-2-oxoethyl]piperidine-4-carboxamide
CAS Number 2139287-33-3
Molecular Formula

C40H52N8O10S2
Molecular Weight (MW) 869.02
SMILES CC(C)(C)C1=CN=C(O1)CSC2=CN=C(S2)NC(=O)C3CCN(CC3)CC(=O)NCCOCCOCCOCCNC4=CC=CC5=C4C(=O)N(C5=O)C6CCC(=O)NC6=O
InChIKey BXDZOYLPNAIDOC-UHFFFAOYSA-N

Biological Activity

THAL-SNS-032 is a selective cyclin-dependent kinase 9 (CDK9) proteolysis-targeting chimera (PROTAC) degrader composed of the CDK inhibitor SNS-032 linked to a cereblon (CRBN) E3 ubiquitin ligase ligand. Targeted proteasomal degradation of CDK9 downregulates Ser2 phosphorylation of the RNA polymerase II C-terminal domain, leading to the inhibition of nascent transcription, suppression of short-lived oncogenic drivers such as MYC, and induction of cell apoptosis. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 100 mg/mL (115.07 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 30 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Reference

[1] Olson CM, et al. Nat Chem Biol. 2018;14(2):163-170.

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Note: Technical data last updated: Sep 1, 2026.