CAS No. 2196203-96-8
Batch:
Purity:99.32
Chemical Structure
Check the
TH34
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 3-(benzylamino)-N-hydroxy-4-methylbenzamide | |
|---|---|---|
| CAS Number | 2196203-96-8 | |
| Molecular Formula |
C15H16N2O2 |
|
| Molecular Weight (MW) | 256.30 | |
| SMILES | CC1=C(C=C(C=C1)C(=O)NO)NCC2=CC=CC=C2 | |
| InChIKey | PZBARTUEWCQNSN-UHFFFAOYSA-N |
TH34 is a selective histone deacetylase (HDAC) inhibitor that exhibits pronounced preference for HDAC6, HDAC8, and HDAC10 over HDAC1, HDAC2, and HDAC3. Cellular target engagement demonstrates low-micromolar binding to HDAC6, HDAC8, and HDAC10. Inhibition of these deacetylase isoforms modulates protein deacetylation and chromatin remodeling, altering cellular transcriptional regulation and cellular proliferation.
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
51 mg/mL
(198.98 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 15 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.