CAS No. 2567914-01-4
Batch:
Purity:99.05
Chemical Structure
Check the
TH1760
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 6-[4-(1H-indole-5-carbonyl)piperazin-1-yl]sulfonyl-3H-1,3-benzoxazol-2-one | |
|---|---|---|
| CAS Number | 2567914-01-4 | |
| Molecular Formula |
C20H18N4O5S |
|
| Molecular Weight (MW) | 426.45 | |
| InChIKey | HNCVDRFFJZJQRW-UHFFFAOYSA-N |
TH1760 is a first-in-class, potent, selective, and cell-active inhibitor of NUDT15 (MTH2). By directly binding into the catalytic pocket of NUDT15, TH1760 inhibits its nucleotide hydrolase function and blocks the clearance of active thiopurine metabolites. Consequently, this target inhibition enhances the accumulation of 6-thio-dGTP in nucleic acids, resulting in the potentiation of thiopurine-induced cytotoxicity and cellular sensitization. [1]
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
7 mg/mL
(16.41 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
11 mg/mL
(25.79 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.