CAS No. 1002801-51-5
Batch:
Purity:99.83
Chemical Structure
Check the
TH10785
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | N-cyclohexyl-2-cyclopropylquinazolin-4-amine | |
|---|---|---|
| CAS Number | 1002801-51-5 | |
| Molecular Formula |
C17H21N3 |
|
| Molecular Weight (MW) | 267.37 | |
| SMILES | C1CCC(CC1)NC2=NC(=NC3=C2C=CC=C3)C4CC4 | |
| InChIKey | ZQMGQZOHIDOPCQ-UHFFFAOYSA-N |
TH10785 is an 8-oxoguanine DNA glycosylase 1 (OGG1) activator that interacts with phenylalanine-319 and glycine-42 residues of OGG1 to increase enzyme activity 10-fold. By controlling catalytic activity through its nitrogen base structure, TH10785 generates a β,δ-lyase function and increases cellular OGG1 recruitment and repair of oxidative DNA damage, shifting base excision repair to a PNKP1-dependent, APE1-independent pathway. [1]
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
53 mg/mL
(198.22 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 53 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.