CAS No. 2847881-42-7
Batch:
Purity:99.01
Chemical Structure
Check the
TH-Z816
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 7-(8-methylnaphthalen-1-yl)-4-[(2R)-2-methylpiperazin-1-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-pyrido[3,4-d]pyrimidine | |
|---|---|---|
| CAS Number | 2847881-42-7 | |
| Molecular Formula |
C29H38N6O |
|
| Molecular Weight (MW) | 486.65 | |
| InChIKey | UAZYYGRPOMNMMP-GGAORHGYSA-N |
TH-Zis an inhibitor of mutant KRAS(G12D) in an SOS-catalyzed nucleotide exchange assay with GDP as the incoming nucleotide). By engaging an induced-fit switch-II pocket and forming a salt bridge with Asp12, TH-Zdisrupts SOS-mediated nucleotide exchange and blocks downstream RAS signaling, ultimately inhibiting mutant KRAS-driven oncogenic phenotypes in cancer cells. [1]
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| Ethanol | 97 mg/mL |
| DMSO |
12 mg/mL
(24.65 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.