CAS No. 1197300-24-5
Batch:
Purity:99.93
Chemical Structure
Check the
TGR5 Receptor Agonist
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 3-(2-chlorophenyl)-N-(4-chlorophenyl)-N,5-dimethyl-1,2-oxazole-4-carboxamide | |
|---|---|---|
| CAS Number | 1197300-24-5 | |
| Molecular Formula |
C18H14Cl2N2O2 |
|
| Molecular Weight (MW) | 361.22 | |
| SMILES | CC1=C(C(=NO1)C2=CC=CC=C2Cl)C(=O)N(C)C3=CC=C(C=C3)Cl | |
| InChIKey | IGRCWJPBLWGNPX-UHFFFAOYSA-N |
TGR5 Receptor Agonist is a potent selective agonist of the G-protein-coupled bile acid receptor TGR5 (GPBAR1/M-BAR). Activation of TGR5 stimulates intracellular cAMP accumulation and protein kinase A signaling, promoting glucagon-like peptide-1 secretion and regulating energy metabolism and glucose homeostasis. This receptor activation influences downstream metabolic pathways and inflammatory responses across diverse mammalian cell types and tissues. [1][2]
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
96 mg/mL
(265.76 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 12 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
- TGR5 Receptor Agonist Clinical Trials
- TGR5 Receptor Agonist Solubility in DMSO
- TGR5 Receptor Agonist Stock Solution
- TGR5 Receptor Agonist Storage
- TGR5 Receptor Agonist Stability
- TGR5 Receptor Agonist Molecular Weight
- TGR5 Receptor Agonist SMILES
- TGR5 Receptor Agonist Chemical Structure (2D and 3D)
- TGR5 Receptor Agonist SDS｜MSDS
Note: Technical data last updated: Sep 1, 2026.