CAS No. 51987-99-6
Batch:
Purity:99.74
Chemical Structure
Check the
TGN020
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | N-(1,3,4-thiadiazol-2-yl)pyridine-3-carboxamide | |
|---|---|---|
| CAS Number | 51987-99-6 | |
| Molecular Formula |
C8H6N4OS |
|
| Molecular Weight (MW) | 206.22 | |
| SMILES | C1=CC(=CN=C1)C(=O)NC2=NN=CS2 | |
| InChIKey | AGEGZHOPKZFKBP-UHFFFAOYSA-N |
TGN020 is a selective aquaporin 4 (AQP4) inhibitor with an IC50 value of. By blocking AQP4-mediated water transport across astrocyte plasma membranes, TGN020 reduces intracellular water accumulation and osmotic imbalance in neural tissues. Inhibition of AQP4 suppresses brain water content, ameliorates cytotoxic edema, and attenuates tissue swelling in animal models of cerebral ischemia and retinal edema.
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Concentration
Volume
Mass
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|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
15 mg/mL
(72.73 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.