CAS No. 1164462-05-8
Batch:
Purity:99.71
Chemical Structure
Check the
TG4-155
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | (E)-N-[2-(2-methylindol-1-yl)ethyl]-3-(3,4,5-trimethoxyphenyl)prop-2-enamide | |
|---|---|---|
| CAS Number | 1164462-05-8 | |
| Molecular Formula |
C23H26N2O4 |
|
| Molecular Weight (MW) | 394.46 | |
| SMILES | CC1=CC2=CC=CC=C2N1CCNC(=O)C=CC3=CC(=C(C(=C3)OC)OC)OC | |
| InChIKey | YBHUXHFZLMFETJ-MDZDMXLPSA-N |
TG4-155 is a potent and selective prostaglandin EP2 receptor antagonist with a Ki of. By selectively blocking EP2 receptor activation, TG4-155 inhibits prostaglandin E2-mediated cyclic AMP accumulation and downstream inflammatory signaling cascades. This target inhibition suppresses microglial activation and reduces pro-inflammatory cytokine expression, demonstrating neuroprotective and anti-inflammatory activity in preclinical models of brain injury. [1]
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
79 mg/mL
(200.27 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 5 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.