CAS No. 936091-14-4

Batch: Purity:99.74
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TG101209 Chemical Structure
Chemical Structure
Check the TG101209 product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name N-tert-butyl-3-[[5-methyl-2-[4-(4-methylpiperazin-1-yl)anilino]pyrimidin-4-yl]amino]benzenesulfonamide
CAS Number 936091-14-4
Molecular Formula

C26H35N7O2S
Molecular Weight (MW) 509.67
SMILES CC1=CN=C(N=C1NC2=CC(=CC=C2)S(=O)(=O)NC(C)(C)C)NC3=CC=C(C=C3)N4CCN(CC4)C
InChIKey JVDOKQYTTYUYDV-UHFFFAOYSA-N

Ordering Information

Biological Activity

TG101209 is a selective small-molecule kinase inhibitor of JAK2 (IC50 6 nM), RET, FLT3, and JAK3. By blocking JAK2 signaling, TG101209 suppresses STAT3 phosphorylation and downstream pathway activation. This inhibition leads to reduced cell proliferation and enhanced apoptosis in myeloproliferative cells harboring JAK2V617F or MPLW515L/K mutations. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 100 mg/mL (196.2 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.