CAS No. 719277-26-6
Chemical Structure
Check the
TG003
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | (1Z)-1-(3-ethyl-5-methoxy-1,3-benzothiazol-2-ylidene)propan-2-one | |
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| CAS Number | 719277-26-6 | |
| Molecular Formula |
C13H15NO2S |
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| Molecular Weight (MW) | 249.33 | |
| SMILES | CC(/C=C1SC2=CC=C(C=C2N\1CC)OC)=O | |
| InChIKey | BGVLELSCIHASRV-QPEQYQDCSA-N |
TG003 is a potent Cdc2-like kinase inhibitor that targets Clk1 (IC50 of and Clk4 (IC50 of. By inhibiting CLK family activity, TG003 prevents the phosphorylation of serine/arginine-rich splicing factors, modulating alternative splicing pathways in mammalian cells. This blockade regulates pre-mRNA splicing machinery, altering gene expression patterns and downstream cellular phenotypes associated with splicing regulation. [1]
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Note: Technical data last updated: Sep 1, 2026.