CAS No. 936091-56-4
Batch:
Purity:98.22
Chemical Structure
Check the
TG-89
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | N-tert-butyl-3-[[5-methyl-2-[3-(morpholin-4-ylmethyl)anilino]pyrimidin-4-yl]amino]benzenesulfonamide | |
|---|---|---|
| CAS Number | 936091-56-4 | |
| Molecular Formula |
C26H34N6O3S |
|
| Molecular Weight (MW) | 510.65 | |
| SMILES | CC1=CN=C(N=C1NC2=CC(=CC=C2)S(=O)(=O)NC(C)(C)C)NC3=CC=CC(=C3)CN4CCOCC4 | |
| InChIKey | OOSKXASFJFSOBK-UHFFFAOYSA-N |
TG-89 is a synthetic small-molecule inhibitor of Janus kinase 2 (JAK2). By targeting JAK2 kinase activity, it blocks downstream activation of the JAK/STAT signaling pathway. This inhibition suppresses STAT protein phosphorylation and nuclear translocation, thereby modulating gene expression profiles involved in cellular proliferation, cell survival, and inflammatory responses in JAK2-dependent cell models. [1]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
10 mg/mL
(19.58 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | ˂1 mg/mL |
| Ethanol | ˂1 mg/mL |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.