CAS No. 925705-73-3
Batch:
Purity:99.96
Chemical Structure
Check the
TG100713
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 3-(2,4-diaminopteridin-6-yl)phenol | |
|---|---|---|
| CAS Number | 925705-73-3 | |
| Molecular Formula |
C12H10N6 |
|
| Molecular Weight (MW) | 254.25 | |
| SMILES | C1=CC(=CC(=C1)O)C2=CN=C3C(=N2)C(=NC(=N3)N)N | |
| InChIKey | UOORQSPLBHUQDQ-UHFFFAOYSA-N |
TG100713 is a pan-PI3K inhibitor that targets PI3Kγ, PI3Kδ, PI3Kα, and PI3Kβ. By suppressing class I PI3K isoforms, TG100713 disrupts downstream AKT/mTOR pathway signaling, reducing endothelial cell migration and capillary morphogenesis. Additionally, it impairs immune cell activation and inflammatory responses in preclinical vascular and ischemic injury models. [1]
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
2 mg/mL
(7.86 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
Looking for a specific aliquot size? Reach out to your local sales representative or contact us at orders@selleckchem.com.
Note: Technical data last updated: Sep 1, 2026.