CAS No. 1011244-68-0
Batch:
Purity:99.93
Chemical Structure
Check the
TFAP
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | N-(5-amino-2-pyridinyl)-4-(trifluoromethyl)benzamide | |
|---|---|---|
| CAS Number | 1011244-68-0 | |
| Molecular Formula |
C13H10F3N3O |
|
| Molecular Weight (MW) | 281.23 | |
| SMILES | C1=CC(=CC=C1C(=O)NC2=NC=C(C=C2)N)C(F)(F)F | |
| InChIKey | BTCFFMPDIBWZLF-UHFFFAOYSA-N |
Biological Activity
TFAP is a selective and cell-permeable cyclooxygenase-1 (COX-1) inhibitor. It targets COX-1 to block the enzymatic conversion of arachidonic acid into prostaglandin H2, effectively suppressing downstream pro-inflammatory eicosanoid biosynthesis and lipid mediator signaling pathways. By inhibiting COX-1 activity, TFAP modulates cellular inflammatory responses, platelet aggregation, and vascular homeostasis phenotypes in preclinical research models. [1]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
56 mg/mL
(199.12 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 56 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Reference
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Note: Technical data last updated: Sep 1, 2026.