CAS No. 16330-92-0
| IUPAC Name | bis(sulfanylidene)molybdenum;sulfanide | |
|---|---|---|
| CAS Number | 16330-92-0 | |
| Molecular Formula |
MoS4 |
|
| Molecular Weight (MW) | 224.20 | |
| SMILES | S=[Mo--;v8](=S)(=S)=S | |
| InChIKey | VVRHUOPINLMZBL-UHFFFAOYSA-L |
Tetrathiomolybdate (TM) is a copper-chelating agent that targets the cellular copper efflux protein ATP7B. It induces dimerization of the metal-binding domain of ATP7B (WLN4) through a unique sulfur-bridged Mo2S6O2 cluster, expelling copper ions from the domain and inhibiting protein platination. By forming sulfur-bridged copper-molybdenum clusters with metallochaperones, TM blocks metal transfer functions between copper-trafficking proteins and down-regulates copper delivery to metalloenzymes. [1][2]
|
Concentration
Volume
Mass
|
|---|
| Solvent | Solubility & Note |
|---|---|
| DMSO |
45 mg/mL
(200.71 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
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- Tetrathiomolybdate (TM) Stock Solution
- Tetrathiomolybdate (TM) Storage
- Tetrathiomolybdate (TM) Stability
- Tetrathiomolybdate (TM) Molecular Weight
- Tetrathiomolybdate (TM) SMILES
- Tetrathiomolybdate (TM) Chemical Structure (2D and 3D)
- Tetrathiomolybdate (TM) SDS｜MSDS