CAS No. 36062-04-1

Batch: Purity:99.86
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Tetrahydrocurcumin Chemical Structure
Chemical Structure
Check the Tetrahydrocurcumin product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 1,7-bis(4-hydroxy-3-methoxyphenyl)heptane-3,5-dione
CAS Number 36062-04-1
Molecular Formula

C21H24O6
Molecular Weight (MW) 372.41
SMILES COC1=C(C=CC(=C1)CCC(=O)CC(=O)CCC2=CC(=C(C=C2)O)OC)O
InChIKey LBTVHXHERHESKG-UHFFFAOYSA-N

Ordering Information

Biological Activity

Tetrahydrocurcumin is a major active metabolite of curcumin that functions as an antioxidant and acts as an inhibitor of cytochrome P450 enzymes, including CYP2C9 and CYP3A4. It effectively attenuates oxidative stress by scavenging reactive oxygen species and reducing lipid peroxidation. Downstream, tetrahydrocurcumin protects against cellular damage, exhibiting significant cardioprotective and anti-inflammatory activity by suppressing pro-inflammatory cascades. [1][2]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 74 mg/mL (198.7 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 50 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.