CAS No. 1883602-21-8
Batch:
Purity:98.56
Chemical Structure
Check the
TES-1025
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 2-[3-[(5-cyano-6-oxo-4-thiophen-2-yl-1H-pyrimidin-2-yl)sulfanylmethyl]phenyl]acetic acid | |
|---|---|---|
| CAS Number | 1883602-21-8 | |
| Molecular Formula |
C18H13N3O3S2 |
|
| Molecular Weight (MW) | 383.45 | |
| SMILES | OC(=O)CC1=CC=CC(=C1)CSC2=NC(=O)C(=C(N2)C3=CC=CS3)C#N | |
| InChIKey | RJQYGCGMQYVVIB-UHFFFAOYSA-N |
TES-1025 is a potent and selective inhibitor of human α-amino-β-carboxymuconate-ε-semialdehyde decarboxylase (ACMSD) with an IC50 of 0.013 μM. By inhibiting ACMSD, the compound modulates de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis and increases intracellular NAD+ levels in cellular systems. Boosting cellular NAD+ pools through this pathway links cellular metabolism to downstream signaling networks and supports metabolic homeostasis. [1]
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Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
38 mg/mL
(99.1 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.