CAS No. 50679-08-8
Batch:
Purity:99.91
Chemical Structure
Check the
Terfenadine
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| CAS Number | 50679-08-8 | |
|---|---|---|
| Molecular Formula |
C32H41NO2 |
|
| Molecular Weight (MW) | 471.67 | |
| SMILES | CC(C)(C)C1=CC=C(C=C1)C(CCCN2CCC(CC2)C(C3=CC=CC=C3)(C4=CC=CC=C4)O)O |
Terfenadine is an H1 histamine receptor antagonist and a potent open-channel blocker of human ether-a-go-go-related gene (hERG) channels. By modulating intracellular calcium homeostasis, terfenadine triggers ROS-dependent apoptosis in melanoma cells. This activation of apoptotic pathways simultaneously engages caspase-4, caspase-2, and caspase-9 downstream, leading to suppressed cell proliferation and enhanced programmed cell death. [1]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
94 mg/mL
(199.29 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 27 mg/mL |
| Water | Insoluble |
| DMSO |
31 mg/mL
(65.72 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 11 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.