CAS No. 1070881-42-3
Batch:
Purity:99.78
Chemical Structure
Check the
Terevalefim
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 5-[(E)-2-thiophen-2-ylethenyl]-1H-pyrazole | |
|---|---|---|
| CAS Number | 1070881-42-3 | |
| Molecular Formula |
C9H8N2S |
|
| Molecular Weight (MW) | 176.24 | |
| SMILES | [NH]1C=CC(=N1)\C=C\C2=CC=CS2 | |
| InChIKey | FOHWAQGURRYJFK-ONEGZZNKSA-N |
Terevalefim (ANG- is a small-molecule hepatocyte growth factor (HGF) mimetic that targets the tyrosine kinase receptor c-MET [1]. By stimulating c-MET dimerization and auto-phosphorylation, it activates downstream signaling through the AKT pathway and upregulates anti-apoptotic proteins such as Bcl-2 [1]. These downstream signaling events suppress cellular apoptosis and promote tubular epithelial cell proliferation, contributing to enhanced cellular survival and tissue repair following ischemic injury [1]. [1]
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Concentration
Volume
Mass
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|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
35 mg/mL
(198.59 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 35 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.