CAS No. 6809-52-5

Batch: Purity:99.69
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Teprenone Chemical Structure
Chemical Structure
Check the Teprenone product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

CAS Number 6809-52-5
Molecular Formula

C23H38O
Molecular Weight (MW) 330.55
SMILES CC(=CCCC(=CCCC(=CCCC(=CCCC(=O)C)C)C)C)C

Biological Activity

Teprenone is an acyclic polyisoprenoid derivative that functions as a potent inducer of heat shock proteins, particularly heat shock protein 70 (HSP70). By promoting the activation and nuclear translocation of heat shock factor 1 (HSF1), Teprenone upregulates intracellular chaperone expression, which enhances protein folding capacity, suppresses oxidative stress-induced cytotoxicity, and maintains cell survival under stress conditions. [1]

How to Prepare Stock Solution?

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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 66 mg/mL (199.66 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Reference

[1] Hirakawa T, et al. Gastroenterology. 1996;111(2):345-57.

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Note: Technical data last updated: Sep 1, 2026.