CAS No. 1011301-27-1
Batch:
Purity:99.95
Chemical Structure
Check the
Tenovin-3
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | N-[(4-aminophenyl)carbamothioyl]-4-tert-butylbenzamide | |
|---|---|---|
| CAS Number | 1011301-27-1 | |
| Molecular Formula |
C18H21N3OS |
|
| Molecular Weight (MW) | 327.44 | |
| SMILES | CC(C)(C)C1=CC=C(C=C1)C(=O)NC(=S)NC2=CC=C(C=C2)N | |
| InChIKey | NLAXTZPUTNGRDU-UHFFFAOYSA-N |
Biological Activity
Tenovin-3 is a small-molecule inhibitor of SIRT2, a class III histone deacetylase that regulates cellular stress responses and protein stability. By targeting SIRT2 deacetylase activity, Tenovin-3 impairs sirtuin-mediated signaling and leads to elevated levels of the tumor suppressor protein p53 in MCF-7 breast cancer cells. Consequently, this p53 pathway activation promotes downstream cell cycle arrest and apoptosis to suppress cancer cell proliferation. [1]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
65 mg/mL
(198.5 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Reference
Jump to
Note: Technical data last updated: Sep 1, 2026.